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- The Ashley Treatment refers to a controversial set of medical procedures performed on an American child, "Ashley X". Ashley, born in 1997, who has severe developmental disabilities due to static encephalopathy; she is assumed to be at an infant level mentally, but continues to grow physically. The treatment included growth attenuation via high-dose estrogens, hysterectomy, bilateral breast bud removal, and appendectomy. In June 2016, after 18 years of searching, Ashley's condition was determined to be the result of a de novo (not inherited, i.e. a mutation) and non-mosaic single-nucleotide polymorphism in the GRIN1 gene, which is implicated in neurotransmission. The principal purpose of the treatment was to improve Ashley's quality of life by limiting her growth in size, eliminating menstrual cramps and bleeding, and preventing discomfort from large breasts. The combination of the surgery and the estrogen therapy attracted much public comment and ethical analysis in early 2007, both supportive and condemning. Ashley's parents granted their first written interview to CNN Health in March 2008,and their second to The Guardian in March 2012.In addition, The Guardian published two interviews with mothers of a girland a boywho had completed the treatment. A 2014 TV program and article tell the similar story of a girl in New Zealand.A survey on growth attenuation among pediatric endocrinologists was published in July 2015. (en)
- Die Ashley-Behandlung bezieht sich auf eine Reihe von kontroversen Behandlungen, welche als Erstes an einem Kind aus Seattle, Ashley X(*), durchgeführt wurden. Ashley wurde 1997 geboren und ist durch statische Enzephalopathie mit damals ungeklärter Ursache schwer geistig behindert. Die Behandlung beinhaltet das vorzeitige Beenden des Wachstums durch Hormonpräparate, Hysterektomie, beidseitige Mastektomie und Appendektomie. Mittlerweile wurde ein Einzelnukleotid-Polymorphismus im GRIN1-Gen entdeckt. Der primäre Sinn dieser Behandlung ist das Verhindern der Bildung sekundärer Geschlechtsmerkmale und des Wachstums zu adulter Größe. Die Kombination dieser Behandlungen erzeugte Anfang 2007 großes öffentliches Interesse und löste ethische Diskussionen aus. (*) Der Nachname von „Ashley X“ ist nicht bekannt. (de)
- アシュリー・トリートメント（Ashley Treatment）、あるいはアシュリー療法は、原因不明の脳症による発達障害を持つ1997年生まれ、シアトル在住の児童「アシュリー X（Ashley X）」に実施され、物議を醸した一連の医療処置。本件は2006年10月に掲載された論文『重度の発達障害を持つ子供の成長減衰: 古いジレンマへの新たなアプローチ』（原題: Attenuating Growth in Children With Profound Developmental Disability: A New Approach to an Old Dilemma）にて発表され、2007年1月3日の『ロサンゼルス・タイムズ』に記事が掲載されたことでアシュリー自身の尊厳を巡る論争が激化した。 (ja)
- 애슐리 치료(Ashley Treatment)는 미국 시애틀의 어린이 "애슐리 X"(완전한 이름을 완전히 밝히지 않기 위해 X를 쓴다.)에게 가해지는, 논란이 있는 일련의 의학적인 치료를 말한다. 애슐리는 1997년에 태어났고, 원인을 모르는 정적인 뇌질환 때문에 발달 장애를 겪고 있다. 이 치료는 호르몬 제제를 통한 성장 방지, 자궁 절제, 양쪽 유방 절제, 맹장 절제를 포함한다. 이 치료는 2차 성징의 진행을 막는 것이 목적이다. (ko)
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- アシュリー・トリートメント（Ashley Treatment）、あるいはアシュリー療法は、原因不明の脳症による発達障害を持つ1997年生まれ、シアトル在住の児童「アシュリー X（Ashley X）」に実施され、物議を醸した一連の医療処置。本件は2006年10月に掲載された論文『重度の発達障害を持つ子供の成長減衰: 古いジレンマへの新たなアプローチ』（原題: Attenuating Growth in Children With Profound Developmental Disability: A New Approach to an Old Dilemma）にて発表され、2007年1月3日の『ロサンゼルス・タイムズ』に記事が掲載されたことでアシュリー自身の尊厳を巡る論争が激化した。 (ja)
- 애슐리 치료(Ashley Treatment)는 미국 시애틀의 어린이 "애슐리 X"(완전한 이름을 완전히 밝히지 않기 위해 X를 쓴다.)에게 가해지는, 논란이 있는 일련의 의학적인 치료를 말한다. 애슐리는 1997년에 태어났고, 원인을 모르는 정적인 뇌질환 때문에 발달 장애를 겪고 있다. 이 치료는 호르몬 제제를 통한 성장 방지, 자궁 절제, 양쪽 유방 절제, 맹장 절제를 포함한다. 이 치료는 2차 성징의 진행을 막는 것이 목적이다. (ko)
- The Ashley Treatment refers to a controversial set of medical procedures performed on an American child, "Ashley X". Ashley, born in 1997, who has severe developmental disabilities due to static encephalopathy; she is assumed to be at an infant level mentally, but continues to grow physically. The treatment included growth attenuation via high-dose estrogens, hysterectomy, bilateral breast bud removal, and appendectomy. In June 2016, after 18 years of searching, Ashley's condition was determined to be the result of a de novo (not inherited, i.e. a mutation) and non-mosaic single-nucleotide polymorphism in the GRIN1 gene, which is implicated in neurotransmission. (en)
- Die Ashley-Behandlung bezieht sich auf eine Reihe von kontroversen Behandlungen, welche als Erstes an einem Kind aus Seattle, Ashley X(*), durchgeführt wurden. Ashley wurde 1997 geboren und ist durch statische Enzephalopathie mit damals ungeklärter Ursache schwer geistig behindert. Die Behandlung beinhaltet das vorzeitige Beenden des Wachstums durch Hormonpräparate, Hysterektomie, beidseitige Mastektomie und Appendektomie. Mittlerweile wurde ein Einzelnukleotid-Polymorphismus im GRIN1-Gen entdeckt. (*) Der Nachname von „Ashley X“ ist nicht bekannt. (de)
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- Ashley-Behandlung (de)
- Ashley Treatment (en)
- アシュリー・トリートメント (ja)
- 애슐리 치료 (ko)
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