The Prausnitz–Küstner test (PK test, Prausnitz-Küstner reaction) is an immunologic test formerly used by physicians to determine if a patient has an allergic reaction to a specific antigen. The test has been replaced by the safer skin prick test. The PK test involves transferring serum from the test subject to another healthy person, essentially using the second person as a mixing vessel for antibodies and antigen. This is a pathway for transmission of blood-borne ailments like variant Creutzfeldt–Jakob disease, AIDS, and others, which is why the test is no longer recommended.Or in simple words, a test for the presence of immediate hypersensitivity in humans; test serum from an atopic individual is injected intradermally into a normal subject; the normal subject is challenged 24–48 hours l
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| - プラウスニッツ・キュストナー反応（プラウスニッツ・キュストナーはんのう）あるいはP-K反応とは、1921年にドイツの医師カール・プラウスニッツとハインツ・キュストナーによって発見された免疫反応である。プラウスニッツはサバに対してアレルギーがあったキュストナーから採取した血清を自身の皮内に注射し、翌日になって同じ個所にサバの抽出液を注射した。その結果、サバに対するアレルギーがなかったプラウスニッツの皮膚にアレルギー反応が生じた。これはキュストナーの血清にサバに対してアレルギーを起こすIgE抗体が存在しており、注射によってプラウスニッツのマスト細胞のIgE受容体に抗体が結合したため、サバに対してアレルギーを起こすようになったのである。1966年、IgE抗体は石坂公成によって精製された。
- Il PK test (chiamato anche Prausnitz Küstner test oppure reazione di Prausnitz Küstner) è un test immunologico molto utilizzato in passato dai medici per determinare se un paziente aveva una reazione allergica ad un antigene specifico.Il test negli ultimi anni è stato sostituito dal più sicuro prick test cutaneo.Il PK test implicava l'inoculazione di una piccola quota di siero dal soggetto in esame ad una persona sana.Questa modalità implica il rischio di trasmissione per via ematica di malattie come l'epatite B e C, il morbo di Creutzfeldt-Jakob, l'AIDS, ed altre ancora, motivo per cui il test non è più raccomandato.Il test costituiva una sorta di reazione per verificare la presenza di ipersensibilità immediata nell'uomo.Una piccola quantità di siero di un individuo atopico veniva iniettata per via intradermica in un soggetto normale.Il soggetto normale 24-48 ore dopo l'inoculo veniva messo a contatto, sempre per via intradermica, con l'antigene sospettato di provocare la reazione di ipersensibilità immediata nell'individuo atopico.
- The Prausnitz–Küstner test (PK test, Prausnitz-Küstner reaction) is an immunologic test formerly used by physicians to determine if a patient has an allergic reaction to a specific antigen. The test has been replaced by the safer skin prick test. The PK test involves transferring serum from the test subject to another healthy person, essentially using the second person as a mixing vessel for antibodies and antigen. This is a pathway for transmission of blood-borne ailments like variant Creutzfeldt–Jakob disease, AIDS, and others, which is why the test is no longer recommended.Or in simple words, a test for the presence of immediate hypersensitivity in humans; test serum from an atopic individual is injected intradermally into a normal subject; the normal subject is challenged 24–48 hours later with the antigen suspected of causing the immediate hypersensitivity reaction in the atopic individual.
- Der Prausnitz-Küstner-Versuch oder die Prausnitz-Küstner-Reaktion stellt einen Test auf eine Allergie vom Soforttyp dar. Er zeigt nach intrakutaner Injektion eines sterilen Allergikerserums beim Nichtsensibilisierten eine örtliche allergisch-hyperergischen Gewebsreaktion. Carl Prausnitz und sein Assistent Heinz Küstner (* 1897) veröffentlichten 1921 die Ergebnisse ihrer Selbstversuche: Küstner war gegen Fisch allergisch und Prausnitz gegen Pollen. Wenn Küstners Serum in die Haut von Prausnitz injiziert wurde, entwickelte sich dort schnell eine entzündliche Quaddel nach der Injektion von Fischantigen. Dieser Versuch wies erstmals hautsensibilisierende Antikörper nach. 1925 wurden sie von Coca und Grove als „Reagine“ bezeichnet und 1967 von K. und T. Ishizaka als IgE identifiziert. Der Prausnitz-Küstner-Versuch war eine wichtige Grundlage der Allergieforschung und wurde auch in der Praxis eingesetzt. Da jedoch Übertragungen von Infektionskrankheiten nicht ausgeschlossen werden können, ist inzwischen die technisch einfachere IgE-Bestimmung an seine Stelle getreten.
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| - プラウスニッツ・キュストナー反応（プラウスニッツ・キュストナーはんのう）あるいはP-K反応とは、1921年にドイツの医師カール・プラウスニッツとハインツ・キュストナーによって発見された免疫反応である。プラウスニッツはサバに対してアレルギーがあったキュストナーから採取した血清を自身の皮内に注射し、翌日になって同じ個所にサバの抽出液を注射した。その結果、サバに対するアレルギーがなかったプラウスニッツの皮膚にアレルギー反応が生じた。これはキュストナーの血清にサバに対してアレルギーを起こすIgE抗体が存在しており、注射によってプラウスニッツのマスト細胞のIgE受容体に抗体が結合したため、サバに対してアレルギーを起こすようになったのである。1966年、IgE抗体は石坂公成によって精製された。
- The Prausnitz–Küstner test (PK test, Prausnitz-Küstner reaction) is an immunologic test formerly used by physicians to determine if a patient has an allergic reaction to a specific antigen. The test has been replaced by the safer skin prick test. The PK test involves transferring serum from the test subject to another healthy person, essentially using the second person as a mixing vessel for antibodies and antigen. This is a pathway for transmission of blood-borne ailments like variant Creutzfeldt–Jakob disease, AIDS, and others, which is why the test is no longer recommended.Or in simple words, a test for the presence of immediate hypersensitivity in humans; test serum from an atopic individual is injected intradermally into a normal subject; the normal subject is challenged 24–48 hours l
- Il PK test (chiamato anche Prausnitz Küstner test oppure reazione di Prausnitz Küstner) è un test immunologico molto utilizzato in passato dai medici per determinare se un paziente aveva una reazione allergica ad un antigene specifico.Il test negli ultimi anni è stato sostituito dal più sicuro prick test cutaneo.Il PK test implicava l'inoculazione di una piccola quota di siero dal soggetto in esame ad una persona sana.Questa modalità implica il rischio di trasmissione per via ematica di malattie come l'epatite B e C, il morbo di Creutzfeldt-Jakob, l'AIDS, ed altre ancora, motivo per cui il test non è più raccomandato.Il test costituiva una sorta di reazione per verificare la presenza di ipersensibilità immediata nell'uomo.Una piccola quantità di siero di un individuo atopico veniva inietta
- Der Prausnitz-Küstner-Versuch oder die Prausnitz-Küstner-Reaktion stellt einen Test auf eine Allergie vom Soforttyp dar. Er zeigt nach intrakutaner Injektion eines sterilen Allergikerserums beim Nichtsensibilisierten eine örtliche allergisch-hyperergischen Gewebsreaktion.
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| - Pk test
- Prausnitz-Küstner-Versuch
- Prausnitz–Küstner test
- プラウスニッツ・キュストナー反応
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| - allergic reaction to a specific antigen.
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